Individuals diagnosed with benign colorectal neoplasia (BCN) are at higher than normal risk of developing further polyps or colorectal cancer (CRC)1. Multiple modifiable diet and lifestyle (D&L) behaviours are associated with CRC risk reduction2. Health promotion interventions can influence these behaviours3. A paucity of evidence exists addressing successful Australian health promotion D&L studies among cohorts diagnosed with BCN. This study investigated the efficacy of two D&L interventions. Ninety six participants were randomly allocated to three groups; Information only (IO), Information only + single Motivational Interview with tailored feedback (MI), and Control (usual care) (C). Sixty two participants completed the 6-month study with attrition evenly distributed across the 3 groups. An action research mixed-methods design was used to determine D&L changes pre- and post-intervention. A validated questionnaire determining key predictors of behaviour change was administered to participants at baseline and 6-month endpoint. In addition dietary intakes were measured at the same time points using 4-day self-reported food intake diaries. While qualitative self-reports suggest improvement in dietary behaviours (78% improvement, p<0.05) for the MI group (p=0.026) after 6-months compared to the IO and C groups, quantitative statistical analysis did not produce similar findings. Total fat and saturated fat intakes were significantly lower (p<0.05) at endpoint for IO (total fat: baseline 78.0 ± 44.9; endpoint 60.9 ± 28.7g/d-1, p<0.001; saturated fat 30.0 ± 18.8; 23.4 ± 11.9, p=0.001) and MI (total fat: baseline 82.4 ± 40.0; endpoint 64.8 ± 29.3,p<0.001; saturated fat 31.1 ± 18.2; 27.1 ± 15.9, p=0.042) compared with C. Although within group improvements for self-reported smoking behaviour and alcohol frequency were statistically significant (p<0.05) over the study duration for all groups, inter-group comparisons showed no significant differences. These results suggest there were no differences in the efficacy of IO and a single MI health promotion tool among a cohort diagnosed with BCN.